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Sentinel 5 Precursor (S5P) was launched on the 13th of October 2017 carrying the TROPOspheric Monitoring Instrument (TROPOMI). TROPOMI on the Sentinel 5 Precursor (S5P) satellite observes the CO global abundance exploiting clear-sky and cloudy-sky Earth radiance measurements in the 2.3 µm spectral range of the shortwave infrared (SWIR) part of the solar spectrum. TROPOMI clear sky observations provide CO total columns with sensitivity to the tropospheric boundary layer. For cloudy atmospheres, the column sensitivity changes according to the light path. Carbon monoxide (CO) is an important atmospheric trace gas for our understanding of tropospheric chemistry. In certain urban areas, it is a major atmospheric pollutant. The main sources of CO are the combustion of fossil fuels, biomass burning, and atmospheric oxidation of methane and other hydrocarbons. Whereas fossil fuel combustion is the main source of CO at Northern mid-latitudes, the oxidation of isoprene and biomass burning play an important role in the tropics.