The RAPID-AMOC (Rapid Climate Change - Atlantic Meridional Overturning Circulation) data set consists of pressure, current velocities, temperature, salinity, density, oxygen, alkalinity, pH, PCO2 and inorganic carbon time series. Measurements are collected by moored instruments deployed in arrays across the Atlantic at approximately 26.5N for the Monitoring the Atlantic Meridional Overturning Circulation at 26.5N (MOC) project and the Atlantic BiogeoChemical Fluxes (ABC Fluxes) project. The data set also consists of conductivity- temperature-depth (CTD) profiles, and ships' underway monitoring system meteorology and surface hydrography collected during the mooring deployment and servicing cruises. The RAPID-AMOC data set follows on from the original Rapid Climate Change (RAPID) Programme oceanographic dataset and the RAPID-WATCH dataset. It spans data collected from 2015 to the present and is intended to continue to collect data until approximately 2020. The main aims of the RAPID-AMOC Programme are to provide oceanographic measurements that continue the long time series of the Atlantic Meridional Overturning Circulation to be derived for use in climate change research. The MOC and ABC Fluxes projects are led by scientists at the National Oceanography Centre in Southampton.