The dataset comprises physical, biogeochemical and biological oceanographic, surface meteorological and benthic measurements. Hydrographic profiles including temperature, salinity, fluorescence, transmissance and suspended sediment concentration were collected at numerous stations, while surface hydrographic (fluorescence, transmissance, sea surface temperature, salinity) and meteorological (irradiance, air temperature, humidity, wind speed/direction) data were collected across the survey areas. Sediment, pore water and water column samples were also collected for biogeochemical analysis, as were biological samples for the purposes of species classification and abundance analyses. The data were collected across the Indian Ocean, Arabian Sea and Pakistan margin areas between March and October 2003. Data collection was undertaken by the RRS Charles Darwin during four cruises: CD145 (12 March 2003 to 9 April 2003), CD146 (12 April 2003 to 30 May 2003), CD150 (22 August 2003 to 15 September 2003) and CD151 (17 September 2003 to 20 October 2003). Conductivity-temperature-depth (CTD) profilers with auxiliary sensors, benthic samplers and nets were deployed from the ship, while underway sensors provided continuous surface ocean, meteorological and bathymetric data. The study was designed to investigate an oxygen-minimum zone (OMZ) in the northern Arabian Sea. Chief Investigators include Gregory L Cowie (University of Edinburgh School of GeoSciences) and Brian J Bett (Southampton Oceanography Centre), while other institutions including the Dunstaffnage Marine Laboratory, University of Liverpool and Netherlands Institute of Ecology were also involved in the research. Data management is being undertaken by BODC. Some of the data are still undergoing processing at BODC and further data are expected from originators in the future.