NERC grant NE/R013535/1. Here we present the dataset collected during a brine-CO2 flow-through test using a synthetic sandstone with oblique fractures, performed under realistic reservoir conditions stress. We monitored geophysical, mechanical and transport properties, for drainage and imbibition conditions, representative of the injection and post-injection stages of the CO2 storage process. We collected ultrasonic P- and S-wave velocities and their respective attenuation factors, axial and radial strains, electrical resistivity, pore pressure, temperature and brine and CO2 partial flows (from which relative permeability was later calculated).